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CG: 7% Full erection (60% rigidity) or experienced intolerance in phase I, n: 6|15 (moved to phase III) Phase II, (n=8): Adequate erection, n: 4|8 (entered phase III) Phase III, (n=10): Partial or full erection, in 85% Other outcomes assessed: Rigidity (absent, partial or full) as assessed by palpation Withdrawals|drop-outs|loss to f|u: n=1 in phase II WDAE: 0 TAE: NR SAE: 0 Ascertainment of outcomes assessed: RigiScan Rigidity Assessment System Author Funding N; study design; eligibility Participants characteristics Diagnosis details Intervention Outcomes Godschalk (1996) 172 Funding source: NR N screened = 13 N randomized = 10 (cross over) IG1|IG2, n = 10 CG, n = NA ITT analysis used for primary outcome: NR Inclusion: 18-75 yr with ED who had experienced penile pain after at least 70% of IC PgE1 self injections at home Exclusion: recent major illness, uncontrolled hypertension, or diabetes, a hx of priapism, Peyronies plaques or laboratory abnormalities greater than 25% above or below accepted normal ranges, use of analgesics Age, range: 18-75 yr Co-morbidities: NR Previous ED treatment: Pg E1 Smoking status: NR Body weight: NR Concomitant medications: NR Duration of ED: NR Underlying disease: NR Psychogenic ED: NR Physiologic ED: NR Mixed ED: NR IG1: PgE1 + sodium bicarbonate (alkaline) IG2: PgE1 alone (acidic) IG1: Dose:PgE1 20 . 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